Novel PET method visualizes protein tangles after traumatic brain injury

A research team from the UK and Sweden has used dynamic flortaucipir-PET imaging to show that single moderate-to-severe traumatic brain injury (TBI) can trigger signs of accumulation of neurodegenerative tau protein and lead to cognitive decline.

The researchers found significant tau build-up in a brain region associated with object recognition, and they observed a correlation between the increased deposits that reduced cognitive abilities among patients with a more severe TBI almost 20 years after their injury (Sci. Transl Med. 10.1126/scitranslmed.aaw1993).

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