De-aging the Virtual Brain: Computational Models Used to Identify Key Brain Targets for Stimulation and Counter Brain Aging

 “We successfully simulated the brain states detected in the older group in a whole-brain computational model. We then applied artificial stimulations in all brain regions of the model, looking for a way to induce a brain state similar to the one observed in the younger participants.”

The team found that some brain areas were optimal to force the transition from the older to the middle-aged regime – and they identified the precuneus, a prominent region of the rich club, as the best target.”

The long-term work of the team in the HPB Flagship was crucial for the creation and investigation of computational models of the human brain supporting transitions between brain states.

In addition to providing new information about how the brain reacts differently to external stimulation depending on age, the study could also lay the groundwork for new therapeutic approaches.

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