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Brain Network Mapping Clarifies Distribution of Cortical Thickness Reductions

Cortical connectivity networks may explain irregular topographic distribution of reduced cortical thickness in patients with schizophrenia, according to research published in American Journal of Psychiatry.

Cortical connectivity networks may explain irregular topographic distribution of reduced cortical thickness in patients with schizophrenia, according to research published in American Journal of Psychiatry.

Researchers compared data from 3 cross-sectional schizophrenia cohorts with healthy controls to characterize the extent and location of reductions in cortical thickness, as well as establish whether cortico-cortical connectivity might explain topographic distribution of reductions in the cortex.

Participants included 70 patients with first-episode psychosis (19 with schizophrenia, 38 with schizophreniform disorder, and 13 with schizoaffective disorder), 153 patients with chronic schizophrenia, and 47 patients with treatment-resistant schizophrenia, as well as corresponding healthy controls (57, 168, and 54, respectively). Neuroimaging data were obtained for all patients.

When compared with the healthy control group, 34, 79, and 106 regions showed significant reductions in cortical thickness in the first-episode psychosis, chronic schizophrenia, and treatment-resistant schizophrenia groups, respectively. None of these 3 patient cohorts exhibited increased cortical thickness. Within the chronic and treatment-resistant schizophrenia groups, the most extensive cortical thickness reductions were found in the frontal and temporal lobes and the insula and cingulate cortex, while the posterior regions demonstrated evidence of reductions in the treatment-resistant group.

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