To start you must fill the reception form and send it to CRM@nbml.ir, New NBML projects can be submitted through mechanisms that will be determined by the responsible committee, then we call you .
yes, there are some forms , such as:
• MRI New Project Checklist .
• TMS New Project Checklist .
• TDCS New Project Checklist.
• FNIRS New Project Checklist.
• EEG New Project Checklist.
No. If pre-production scan time is needed for testing of protocols, etc. You may apply for pilot project that involves technical development, but pilot studies are not "free" or "discounted" scans.
1. Burn the data onto a CD/DVD during your scanning session.
2. Transfer the data electronically to a designated server which you can then access the data.
Several computers are available in the user's computer room.
Transcranial Electrical Stimulation is a non-invasive stimulation which applies a 1-2mA direct electrical current between anodal and cathodal electrodes to make excitation or inhibition in subsequent brain regions. Different electrode montages are used in various brain regions, and simulation of input and output electrical current helps to improve montage and affects cognition and disease.
It’s determining and positioning electrodes on the brain regions, shoulder and arm to make the desired function and electrical current path. For each treatment and cognitive assessment, there are different electrode positioning.
tES facilities are explained in Services and equipment section on our webpage, in detail. https://nbml.ir/EN/services/tDCS-Lab
In direct current stimulation, running a session require information of anode, cathode and reference (if it is needed) electrode position, current intensity, stimulation duration, ramp up and ramp down times. In alternative current stimulation current frequency and phase are needed in addition.
In TMS there is a magnetic field in the coil which induces an electrical current and field in 0.5 cm2 and about 2cm depth on the brain and can cause cortex activity, e.g., stimulating motor cortex causes muscle activation. In tES a small direct electrical current is used on 1 to 35 cm2 (each electrode) brain region to make effects.
Electroencephalography (EEG) is a non-invasive technique for measurement of the electrical activity of the brain; EEG has a high temporal resolution compared to other brain mapping techniques.
Electroencephalography can be used as a tool to evaluate and model brain function during cognitive tasks. Besides, evaluation of medical interventions effects such as (transcranial electrical/magnetic stimulation, medication, and therapeutic consultation) is achievable with pre/post electroencephalography. For more information, please visit the service section on our webpage.
We can measure the individual’s response to visual, auditory, somatosensory (vibration, electrical) stimuli.
The lab is equipped with
- (64+16) 80 channel amplifier g.HIamp (g.tec)
- 32 channel amplifier g.USBamp (g.tec)
- 32 channel EEG cap g.Nautilus (g.tec)
- (64+16) 80 channel MR-compatible amplifier BrainAmp MR Plus (Brain Product)
- Set of sensors for physiological parameters recording
It’s recommended to use common toolboxes such as Psychtoolbox & Cogent to implement various cognitive tasks. Use of any programs or scripts written in other programming languages than MATLAB is approved.
Three main approaches can be taken to send synchronization triggers to the digital input of an amplifier?
1- Sending triggers to the parallel port on the stimulation PC. (Click to receive the sample code for parallel port handling)
2- Using optical sensors that are sensitive to changes in illumination intensity. (If you put these sensors on a point on the presentation screen that would change simultaneously with an important event in your tasks such as stimulus presentation or user’s response you will have the time tags on your EEG data.
3- Using Push buttons to mark any desired time points in your data.
Each session, the lab provides you with the recorded signals and synchronization triggers in a single file with .mat format that can be loaded in MATLAB easily.
In case you can receive the approximate electrode coordinates from our lab specialist. Also, there is an opportunity to extract the precise electrode locations using the Navigation system available in the TMS lab.
rTMS is an effective, non-invasive alternative for the large number of patients not responding to medication. rTMS does not require anesthesia – and is not to be confused with ECT (Electro Convulsive Therapy). The rTMS system delivers magnetic pulses to stimulate nerve cells in the part of the brain controlling the mood. The rapid change in the magnetic field induces a current, and if the current induced is of sufficient amplitude and duration, it will excite neurons.
rTMS is well-tolerated and associated with few side-effects and only a small percentage of patients discontinue treatment because of these. The most common side-effect, which is reported in about half of patients treated with rTMS, is headaches. These are mild and generally diminish over the course of the treatment. Over-the-counter pain medication can be used to treat these headaches.
About one third of patients may experience painful scalp sensations or facial twitching with rTMS pulses. These too tend to diminish over the course of treatment although adjustments can be made immediately in coil positioning and stimulation settings to reduce discomfort.
The rTMS machine produces a loud noise and because of this earplugs are given to the patient to use during the treatment. However, some patients may still complain of hearing problems immediately following treatment. No evidence suggests these effects are permanent if earplugs are worn during the treatment.
rTMS has not been associated with many of the side-effects caused by antidepressant medications, such as gastrointestinal upset, dry mouth, sexual dysfunction, weight gain, or sedation.
The most serious risk of rTMS is seizures. However, the risk of a seizure is exceedingly low. At Johns Hopkins, we follow up-to-date safety guidelines that are designed to minimize the risk of seizures. While rTMS is a safe procedure, it is important to point out that because it is a new treatment, there may be unforeseeable risks that are not currently recognized.
Patients with any type of non-removable metal in their heads (with the exception of braces or dental fillings), or within twelve inches of the coil should not receive rTMS. Failure to follow this rule could cause the object to heat up, move, or malfunction, and result in serious injury or death. The following is a list of metal implants that can prevent a patient from receiving rTMS:
• Aneurysm clips or coils
• Stents in the neck or brain
• Implanted stimulators
• Cardiac pacemakers or implantable cardioverter defibrillator (ICD)
• Electrodes to monitor brain activity
• Metallic implants in your ears and eyes
• Shrapnel or bullet fragments in or near the head
• Facial tattoos with metallic or magnetic-sensitive ink
• Other metal devices or object implanted in or near the head
No, the most common side effect related to treatment was scalp discomfort during treatment sessions. This side effect was generally mild to moderate, and occurred less frequently after the first week of treatment.
If necessary, you can treat this discomfort with an over-the-counter analgesic. If these side effects persist, your doctor can temporarily reduce the strength of the magnetic field pulses being administered in order to make treatment more comfortable.
Less than 5% of patients treated with TMS Therapy system discontinued treatment due to side effects.
For each rTMS session, the patient sits in a specially designed treatment chair, much like the kind used in a dentist’s office. Because rTMS uses magnetic pulses, before beginning a treatment, patients are asked to remove any magnetic-sensitive objects (such as jewelry, credit cards). Patients are required to wear earplugs during treatment for their comfort and hearing protection, as rTMS produces a loud clicking sound with each pulse, much like an MRI machine.
During the first rTMS session, several measurements are made to ensure that the TMS coil will be properly positioned over the patient’s head. Once this is done, the TMS coil is suspended over the patient’s scalp. The TMS physician then measures the patient’s motor threshold, by administering several brief pulses. The motor threshold is the minimum amount of power necessary to make the patient’s thumb twitch, and varies from individual to individual. Measuring the motor threshold helps the physician personalize the treatment settings and determine the amount of energy required to stimulate brain cells.
Once the motor threshold is determined, the coil is then brought forward so that it rests above the front region of the patient’s brain. Treatment is then commenced. During the treatment, patients will hear a series of clicking sounds and will feel a tapping sensation under the treatment coil.
Succeeding treatment sessions do not require that the motor threshold be determined again, unless indicated otherwise, such as when changes in medications are made during the course of the treatment.
For an rTMS session researcher should determine waveform, coil type, coil positioning on brain, intensity in %Motor threshold, frequency, pulse number in each train or train duration, inter-train interval, total number of train according to safety articles.
We can detect the MEP response of a specific brain area by TMS pulse. The MEP detected with surface electromyography (EMG) quantifies the level of the corticospinal tract and corticobulbar tract excitability (spatially in neurological disorders). For example, when TMS is applied over M1, it can elicit contraction in contralateral muscles.
There are 3 EMG acquisition systems for concurrent TMS-EMG such as:
• Magventure EMG system
• Motion Lab EMG system
• Wireless and wired Bayamed EMG system
Yes, we provide EMG signal analysis service in NBML.
You will be provided by the EMG output files in the .xlsx or .txt formats as well as motor thresholds.
Yes, we can adjust EMG system parameters as you want such as sampling frequency, number of channels, bandwidth, magnification and ….
functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive technique for measurement of the hemodynamic response that monitors the relative changes in the concentrations of (de)oxyhemoglobin.
functional Near-Infrared Spectroscopy can be used as a tool to evaluate and model brain function during cognitive tasks. Besides, evaluation of medical interventions effects such as (transcranial electrical/magnetic stimulation, medication, and therapeutic consultation) is achievable with pre/post functional Near-Infrared Spectroscopy. For more information, please visit the service section on our webpage.
In this lab, we can record fNIRS simultaneously with all other modalities including functional Magnetic Resonance Imaging (fMRI), Electroencephalography (EEG), Transcranial Electrical Stimulation (TES), Transcranial Magnetic Stimulation (TMS), Virtual Reality (VR) and Eye-tracking.
We can measure the individual’s response to visual, auditory, somatosensory (electrical) stimuli.
The lab is equipped with the 48-channel device with MR-compatible fiber optics
It’s recommended to use common toolboxes such as psychtoolbox & Cogent to implement various cognitive tasks. Use of any program or script written in other programming languages than Matlab is approved.
Sending triggers through parallel port on stimulation PC is the way to synchronize task flow and data recording.
Each session, the lab provides you with the recorded signals and synchronization triggers in a single file with .xls , .oxy3, .xml.
In case you can receive the approximate optode coordinates from our lab specialist. Also, there is an opportunity to extract the precise optode location using the Navigation system available in the TMS lab.
Yes, raw data can be exported and saved to a temporary network account folder.
• TWIX data must be saved immediately after the scan session.
• .rda can be exported and saved at any point while the scan is still on the scanner console computer.
The Siemens MR scanners use DICOM as their native file format and this format must be used for CD's burned from the console.
No. The stimulation protocol information is used to create t-test images as part of automatic data processing. This assumes a simple on-off protocol. You can use this feature if you want, but its validity should have no impact on the raw data that you collect. When appropriate, you may find t-test image helpful in providing an early look at your data (e.g., in deciding whether a pre-surgical fMRI study is of good quality).
Most fMRI processing software that reads native DICOM data is now able to handle Siemens mosaic data. The scanner software does include an option for reversing this "mosaicked" process. However, this will create an enormous number of files since each slice is saved as a separate file.
All electrical equipment needs to be reviewed to assure that it is implemented in a way that does not introduce electrical noise into the scanner environment. All objects to be brought into the scanner room must first be screened to assure that they are MR safe. A powerful handheld magnet is available for such screening.
NBML MR scanner has a wide range of different types of structural and functional MRI pulse sequences including 3D volume imaging, T1-weighted and T2-weighted multislice imaging, BOLD fMRI, ALS, diffusion imaging (DWI, ADC and DTI), angiography (MRA), single and multiple voxel proton spectroscopy (MRS) and single slice spectroscopic imaging (CSI).
Multi-nuclear spectroscopy (i.e., spectroscopy of nuclei other than protons) is also supported.
This is not accessible yet.
Yes. It is possible to record ECG, pulse and respirations employing PMU system.
This laboratory services are divided into two main categories, which include EEG data processing and task implementation. EEG data processing is also performed in the fields of time and frequency analysis, ERP analysis and QEEG analysis.
The results obtained from the analysis can be presented in MATLAB, Excel, and image formats according to the choice of the researcher.
Signal processing laboratory services include a specific range of analysis such as frequent time & frequency domain features, and plotting scalp topographies. Some services such as classification, implementation of machine learning algorithms and extraction of connectivity features are not provided for now.
The data analysis is done in the MATLAB program using the EEGLAB and BBCI toolboxes, and the Psychtoolbox and BCI2000 toolboxes are used for task designing.
At the beginning of the project, the researchers (student and professor) will receive an email from the lab expert who is responsible for their project. If there is any further questions or problems regarding the project, they can contact the relevant expert by using the provided email.
The lab has made it possible for researchers to get the results of the pilot data earlier than the designated time so that they can make possible adjustments to their final protocol. It is worth noting that only pilot data analysis is done out of turn and the continuation of the project will be done according to the given time.
A range of cognitive functions such as memory, attention, speed of information processing, ability to reason, judgment, problem solving, linguistic functions, language skills, etc., along with behavioral and emotional functions, are evaluated in cognitive assessment.
CANTAB measures cognitive function, and identifies levels of performance and impairment in the brain. The technology is used in thousands of clinical trials, hospitals, and academic institutions around the world.
Attention and Psychomotor Speed
Emotion and Social Cognition
Alzheimer's - Attention deficit disorders - Autism - Depression and affective disorders - Down's syndrome - Epilepsy - Huntington's disease - Multiple sclerosis - Obsessive compulsive disorder - Parkinson's disease – Schizophrenia - Stroke - Traumatic brain injury
CANTAB is language-independent, culturally neutral, and non-invasive and require no prior knowledge to work with computers.
Currently, imaging data are available including MRI, CT and X-ray. Biosignals and cognitive as well as clinical assessments will be added to the biobank shortly.
At this phase a technical report is attached to each specimen and provided to the researcher. A clinical structured report for images and biosignals will be added to the biobank in next phases.
Any researcher can create an account on the website: ibmb.nbml.ir for free and after defining a particular research project, the requested samples will be delivered to the researcher upon availability. Further information on step by step interaction with IBMB is available through the website. IBMB services are free at the moment.
IBMB is ready to exchange MOUs with any person or institution who has research data. They will gain different kinds of benefits including free access to NBML services.
After submitting a request, the samples and attached information will be available after two working days should the request fulfill the criteria and get approval by the IBMB office and NBML.
All sample are published in IBMB after obtaining informed consent from the patient. Also, all research data will become available for use by written permission of the researcher who are able to set the sample availability conditional.
There is a wide range of MRI modalities that we have routine analysis procedures for them, including Resting State and Task-Based fMRI, DWI-DTI, Relaxometry, Magnetic Resonance Spectroscopy, and Arterial Spin Labeling (ASL). For more information, please refer to the image analysis tab, services, and infrastructures part.
Unfortunately, not yet. We just accept MRI image processing for now.
It is highly recommended that you first request for a pilot analysis service. This approach will help you optimize your study design. Finally, after finishing your data acquisition, you can apply for your complete image processing service.
The duration of analysis varies depending on the imaging modality and analysis approach, but it cannot be expected to receive the results less than a month after giving complete data set to image processing lab.
It depends on the time that you apply for your service. For now, our strategy is first in first serve.
Yes, you need to pay for each analysis separately according to predefined price.
Yes, depending on the study and software or toolbox, the statistical results will also be presented to the researcher.
Depending on the imaging modality, it varies between 45 minutes to 2 hours.
Due to large volume of image processing results they can receive their analysis results on External-Hard driver or flash memory.
Yes, we perform analysis according to application form.
The virtual reality lab is equipped with two setups: HTC Vive Pro and Oculus rift
For Oculus Rift setup, it is a rectangle with a diameter less than 5m, and for HTC Vive, it is a rectangle with 3m diameter.
If the requested game is already available, it can be purchased by the Lab and the cost will be taken from the researcher later.
For now, we do not have any game programming service, but we can provide you with some programming companies contacts.
Yes, there are some limitations regarding experimental conditions for concurrent TMS-VR.
Not for now
No, our devices are not MRI-Compatible.