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New imaging method reveals lack of key brain protein in schizophrenia

A team of UK researchers has, for the first time in living human brains, demonstrated how the cognitive dysfunction seen in schizophrenia may be caused by...

A team of UK researchers has, for the first time in living human brains, demonstrated how the cognitive dysfunction seen in schizophrenia may be caused by the lack of a key protein known to facilitate communication between neurons in the brain.

“Our current treatments for schizophrenia only target one aspect of the disease – the psychotic symptoms – but the debilitating cognitive symptoms, such as loss of abilities to plan and remember, often cause much more long-term disability and there’s no treatment for them at the moment,” explains Oliver Howes, lead researcher on the new study. “Synaptic loss is thought to underlie these symptoms.”

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